| Cytomegalovirus ... infected the majority of the adult US population ... demonstrated by the presence of antibodies in the serum of most adults ... infection remains latent (is not active) ... causes mild to no symptoms at all ... this virus ... can be life-threatening in immune compromised people, notably babies ... It is part of the group of TORCH agents (Toxoplasmosis, Rubella, CMV, and Herpes simplex) ... shown to cause significant problems in pregnancy. Women with active CMV infections (who have acquired the virus while pregnant) can pass the virus to their unborn child ... increased risk for ... enlarged spleen and liver (heptosplenomegaly), as well as problems with hearing, coordination, and mental abilities, and in rare cases, even death ... CMV is commonly transferred by saliva ... |
Congenital Cytomegalovirus
National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases , February 6, 2006
 "... a good source of information ..."
Congenital Cytomegalovirus (CMV) Infection and Disease
Myrna R. Nieves, MD FAAP, Pediatric Bulletin
[for Professionals mainly]
Cytomegalovirus is a member of the herpesviridae family of a large DNA viruses, along with herpes simplex virus types 1 and 2, Epstein-Barr virus, varicela-zoster virus, and human herpesviruses 6 and 7 ... Cytomegalovirus is spread 1) by close or intimate contact of either a sexual or nonsexual nature with another person who is shedding the virus in bodily secretions, 2) vetically from mother to infant, or 3) by blood product transmission from CMV seropositive donor. Infection with cytomegalovirus can be classified as either primary or recurrent ... Aproximately 1% of all newborns are congenitally infected with CMV ... The average rate of transmission to the fetus in primary maternal infection is 40% with reported ranges of 24-75% ...
Cytomegalovirus, splenomegaly
Donna Chriss-Price et al, TheFetus.net, 2004
Cytomegalovirus preferentially invades the salivary glandsand, in infants, the germinal matrix, but can infect other organ cells with development of characteristic cytoplasmic or nuclear inclusion bodies ... Prognosis: Neonatal symptomatology of microcephaly, intracranial abnormalities, and seizures are poor prognostic signs. Previous longitudinal studies have indicated that the majority of symptomatic infants have permanent visual, motor, or intelletual disabilities ...
National Congenital CMV Disease Registry
Baylor College of Medicine, Department of Pediatrics, September 19, 2006
CMV Updates ... What is the National CMV Registry? ...
What Everyone Should Know About CMV
Baylor College of Medicine, Department of Pediatrics, September 20, 2006
Cytomegalovirus infection
I.B.I.S. Birth Defects, August 4, 2002
[Ukrainian]
A fact sheet in Ukrainian for parents.
Mechanism of infection transmission ... Cytomegalovirus and pregnancy ... Clinical forms of congenital cytomegalovirus infection ... Complications ... Diagnosis ... Treatment
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Last Updated: 2007/08/30
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